Retinoblastoma Is Characterized by a Cold, CD8+ Cell Poor, PD-L1− Microenvironment, Which Turns Into Hot, CD8+ Cell Rich, PD-L1+ After Chemotherapy

PURPOSE: To investigate the impact of chemotherapy (CHT) on human retinoblastoma (RB) tumor microenvironment (TME). CASES AND METHODS: Ninety-four RBs were studied, including 44 primary RBs treated by upfront surgery (Group 1) and 50 primary RBs enucleated after CHT (CHT), either intra-arterial (IAC...

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Detalhes bibliográficos
Publicado no:Invest Ophthalmol Vis Sci
Main Authors: Miracco, Clelia, Toti, Paolo, Gelmi, Maria Chiara, Aversa, Sara, Baldino, Gennaro, Galluzzi, Paolo, De Francesco, Sonia, Petrelli, Federica, Sorrentino, Ester, Belmonte, Giuseppe, Galimberti, Daniela, Bracco, Sandra, Hadjistilianou, Theodora
Formato: Artigo
Idioma:Inglês
Publicado em: The Association for Research in Vision and Ophthalmology 2021
Assuntos:
Retina
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7862737/
https://ncbi.nlm.nih.gov/pubmed/33538768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.62.2.6
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