HIF-1α Protects Granulosa Cells From Hypoxia-Induced Apoptosis During Follicular Development by Inducing Autophagy

Owing to the avascular structure of the ovarian follicle, proliferation of granulosa cells (GCs) and development of follicles occur under hypoxia, which is obviously different from the cell survival requirements of most mammalian cells. We hypothesized that autophagy may exert an inhibitory effect o...

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Detalhes bibliográficos
Publicado no:Front Cell Dev Biol
Main Authors: Tang, Zonghao, Xu, Renfeng, Zhang, Zhenghong, Shi, Congjian, Zhang, Yan, Yang, Hongqin, Lin, Qingqiang, Liu, Yiping, Lin, Fengping, Geng, Baorong, Wang, Zhengchao
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7862574/
https://ncbi.nlm.nih.gov/pubmed/33553188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.631016
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