Metformin inhibits pancreatic cancer metastasis caused by SMAD4 deficiency and consequent HNF4G upregulation

Pancreatic ductal adenocarcinoma (PDAC) has poor prognosis due to limited therapeutic options. This study examines the roles of genome-wide association study identified PDAC-associated genes as therapeutic targets. We have identified HNF4G gene whose silencing most effectively repressed PDAC cell in...

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Vydáno v:Protein Cell
Hlavní autoři: Wang, Chengcheng, Zhang, Taiping, Liao, Quan, Dai, Menghua, Guo, Junchao, Yang, Xinyu, Tan, Wen, Lin, Dongxin, Wu, Chen, Zhao, Yupei
Médium: Artigo
Jazyk:Inglês
Vydáno: Higher Education Press 2020
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7862466/
https://ncbi.nlm.nih.gov/pubmed/32737864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13238-020-00760-4
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