Kap1 regulates the self-renewal of embryonic stem cells and cellular reprogramming by modulating Oct4 protein stability

Oct4 plays a crucial role in the regulation of self-renewal of embryonic stem cells (ESCs) and reprogramming of somatic cells to induced pluripotent stem cells. However, the molecular mechanisms underlying posttranslational regulation and protein stability of Oct4 remain unclear. Using affinity puri...

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Опубликовано в: :Cell Death Differ
Главные авторы: Do, Eun Kyoung, Moon, Hye Ji, Kang, Kyung Taek, Yoon, Jung Won, Kim, Ye Seul, Seo, Jeong Kon, Kim, Jae Ho
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2020
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7862287/
https://ncbi.nlm.nih.gov/pubmed/32895487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-020-00613-x
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