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SPT6 promotes epidermal differentiation and blockade of an intestinal-like phenotype through control of transcriptional elongation

In adult tissue, stem and progenitor cells must tightly regulate the balance between proliferation and differentiation to sustain homeostasis. How this exquisite balance is achieved is an area of active investigation. Here, we show that epidermal genes, including ~30% of induced differentiation gene...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Li, Jingting, Xu, Xiaojun, Tiwari, Manisha, Chen, Yifang, Fuller, Mackenzie, Bansal, Varun, Tamayo, Pablo, Das, Soumita, Ghosh, Pradipta, Sen, George L.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2021
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7862286/
https://ncbi.nlm.nih.gov/pubmed/33542242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21067-w
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