Elevated preoptic brain activity in zebrafish glial glycine transporter mutants is linked to lethargy-like behaviors and delayed emergence from anesthesia

Delayed emergence from anesthesia was previously reported in a case study of a child with Glycine Encephalopathy. To investigate the neural basis of this delayed emergence, we developed a zebrafish glial glycine transporter (glyt1 − / −) mutant model. We compared locomotor behaviors; dose–response c...

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Gepubliceerd in:Sci Rep
Hoofdauteurs: Venincasa, Michael J., Randlett, Owen, Sumathipala, Sureni H., Bindernagel, Richard, Stark, Matthew J., Yan, Qing, Sloan, Steven A., Buglo, Elena, Meng, Qing Cheng, Engert, Florian, Züchner, Stephan, Kelz, Max B., Syed, Sheyum, Dallman, Julia E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2021
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7862283/
https://ncbi.nlm.nih.gov/pubmed/33542258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-82342-w
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