Mutated clones driving leukemic transformation are already detectable at the single-cell level in CD34-positive cells in the chronic phase of primary myelofibrosis

Disease progression of myeloproliferative neoplasms is the result of increased genomic complexity. Since the ability to predict disease evolution is crucial for clinical decisions, we studied single-cell genomics and transcriptomics of CD34-positive cells from a primary myelofibrosis (PMF) patient w...

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Dades bibliogràfiques
Publicat a:NPJ Precis Oncol
Autors principals: Parenti, Sandra, Rontauroli, Sebastiano, Carretta, Chiara, Mallia, Selene, Genovese, Elena, Chiereghin, Chiara, Peano, Clelia, Tavernari, Lara, Bianchi, Elisa, Fantini, Sebastian, Sartini, Stefano, Romano, Oriana, Bicciato, Silvio, Tagliafico, Enrico, Della Porta, Matteo, Manfredini, Rossella
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7862275/
https://ncbi.nlm.nih.gov/pubmed/33542466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41698-021-00144-9
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