Simultaneous quantification method for 5-FU, uracil, and tegafur using UPLC-MS/MS and clinical application in monitoring UFT/LV combination therapy after hepatectomy

Combination therapy of tegafur/uracil (UFT) and leucovorin (LV) is widely used to treat colorectal cancers. Although this therapy has a significant therapeutic effect, severe adverse effects occur frequently. Therapeutic drug monitoring (TDM) may help to prevent adverse effects. A useful assay that...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Shiraiwa, Ken, Suzuki, Yosuke, Uchida, Hiroki, Iwashita, Yukio, Tanaka, Ryota, Iwao, Motoshi, Tada, Kazuhiro, Hirashita, Teijiro, Masuda, Takashi, Endo, Yuichi, Inomata, Masafumi, Itoh, Hiroki
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2021
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7862254/
https://ncbi.nlm.nih.gov/pubmed/33542452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-82908-8
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