Dimerisation of the PICTS complex via LC8/Cut-up drives co-transcriptional transposon silencing in Drosophila

In animal gonads, the PIWI-interacting RNA (piRNA) pathway guards genome integrity in part through the co-transcriptional gene silencing of transposon insertions. In Drosophila ovaries, piRNA-loaded Piwi detects nascent transposon transcripts and instructs heterochromatin formation through the Panor...

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Bibliografske podrobnosti
izdano v:eLife
Main Authors: Eastwood, Evelyn L, Jara, Kayla A, Bornelöv, Susanne, Munafò, Marzia, Frantzis, Vasileios, Kneuss, Emma, Barbar, Elisar J, Czech, Benjamin, Hannon, Gregory J
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2021
Teme:
Chromosomes and Gene Expression
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7861614/
https://ncbi.nlm.nih.gov/pubmed/33538693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.65557
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