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Episodic evolution of coadapted sets of amino acid sites in mitochondrial proteins

The rate of evolution differs between protein sites and changes with time. However, the link between these two phenomena remains poorly understood. Here, we design a phylogenetic approach for distinguishing pairs of amino acid sites that evolve concordantly, i.e., such that substitutions at one site...

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Veröffentlicht in:PLoS Genet
Hauptverfasser: Neverov, Alexey D., Popova, Anfisa V., Fedonin, Gennady G., Cheremukhin, Evgeny A., Klink, Galya V., Bazykin, Georgii A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2021
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7861529/
https://ncbi.nlm.nih.gov/pubmed/33493156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008711
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