Polygenic risk score validation using Korean genomes of 265 early-onset acute myocardial infarction patients and 636 healthy controls

BACKGROUND: The polygenic risk score (PRS) developed for coronary artery disease (CAD) is known to be effective for classifying patients with CAD and predicting subsequent events. However, the PRS was developed mainly based on the analysis of Caucasian genomes and has not been validated for East Asi...

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Veröffentlicht in:PLoS One
Hauptverfasser: Bhak, Youngjune, Jeon, Yeonsu, Jeon, Sungwon, Yoon, Changhan, Kim, Min, Blazyte, Asta, Kim, Yeonkyung, Kang, Younghui, Kim, Changjae, Lee, Sang Yeub, Bae, Jang-Whan, Kim, Weon, Kim, Yeo Jin, Shim, Jungae, Kim, Nayeong, Chun, Sung, Kim, Byoung-Chul, Kim, Byung Chul, Lee, Semin, Bhak, Jong, Shin, Eun-Seok
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2021
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7861392/
https://ncbi.nlm.nih.gov/pubmed/33539413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0246538
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