N-Glycans and sulfated glycosaminoglycans contribute to the action of diverse Tc toxins on mammalian cells

Tc toxin is an exotoxin composed of three subunits named TcA, TcB and TcC. Structural analysis revealed that TcA can form homopentamer that mediates the cellular recognition and delivery processes, thus contributing to the host tropism of Tc toxin. N-glycans and heparan sulfates have been shown to a...

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Udgivet i:PLoS Pathog
Main Authors: Song, Nan, Chen, Lihong, Ren, Xingmei, Waterfield, Nicholas R., Yang, Jian, Yang, Guowei
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7861375/
https://ncbi.nlm.nih.gov/pubmed/33539469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1009244
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