Sulfated glycosaminoglycans and low-density lipoprotein receptor contribute to Clostridium difficile toxin A entry into cells

Clostridium difficile toxin A (TcdA) is a major exotoxin contributing to disruption of the colonic epithelium during C. difficile infection. TcdA contains a carbohydrate-binding CROPs (combined repetitive oligopeptides) domain that mediates its attachment to cell surfaces, but recent data suggest th...

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Detalhes bibliográficos
Publicado no:Nat Microbiol
Main Authors: Tao, Liang, Tian, Songhai, Zhang, Jie, Liu, Zhuoming, Robinson-McCarthy, Lindsey, Miyashita, Shin-Ichiro, Breault, David T., Gerhard, Ralf, Oottamasathien, Siam, Whelan, Sean, Dong, Min
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6754795/
https://ncbi.nlm.nih.gov/pubmed/31160825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41564-019-0464-z
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