Human cholesteryl ester transfer protein lacks lipopolysaccharide transfer activity, but worsens inflammation and sepsis outcomes in mice

Bacterial lipopolysaccharides (LPSs or endotoxins) can bind most proteins of the lipid transfer/LPS-binding protein (LT/LBP) family in host organisms. The LPS-bound LT/LBP proteins then trigger either an LPS-induced proinflammatory cascade or LPS binding to lipoproteins that are involved in endotoxi...

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Vydáno v:J Lipid Res
Hlavní autoři: Dusuel, Aloïs, Deckert, Valérie, Pais de Barros, Jean-Paul, van Dongen, Kevin, Choubley, Hélène, Charron, Émilie, Le Guern, Naig, Labbé, Jérôme, Mandard, Stéphane, Grober, Jacques, Lagrost, Laurent, Gautier, Thomas
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2020
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7859855/
https://ncbi.nlm.nih.gov/pubmed/33500240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.RA120000704
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