MDM4 inhibition: a novel therapeutic strategy to reactivate p53 in hepatoblastoma

Hepatoblastoma (HB) is the most common pediatric liver malignancy. High-risk patients have poor survival, and current chemotherapies are associated with significant toxicities. Targeted therapies are needed to improve outcomes and patient quality of life. Most HB cases are TP53 wild-type; therefore,...

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發表在:Sci Rep
Main Authors: Woodfield, Sarah E., Shi, Yan, Patel, Roma H., Chen, Zhenghu, Shah, Aayushi P., Srivastava, Rohit K., Whitlock, Richard S., Ibarra, Aryana M., Larson, Samuel R., Sarabia, Stephen F., Badachhape, Andrew, Starosolski, Zbigniew, Ghaghada, Ketan B., Sumazin, Pavel, Annis, D. Allen, López-Terrada, Dolores, Vasudevan, Sanjeev A.
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2021
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7859402/
https://ncbi.nlm.nih.gov/pubmed/33536467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-82542-4
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