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The heptamer sgRNA targeting the human OCT4 mRNA can upregulate the OCT4 expression

TRUE gene silencing is one of the gene suppression technologies. This technology exploits the enzymatic property of the tRNA 3′ processing endoribonuclease tRNase Z(L), which is that it can cleave a target RNA under the direction of a small guide RNA (sgRNA). We have been working on the development...

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Détails bibliographiques
Publié dans:Biochem Biophys Rep
Auteurs principaux: Nozaki, Tadasuke, Takahashi, Masayuki, Ishikawa, Tatsuya, Haino, Arisa, Seki, Mineaki, Kikuchi, Hidetomo, Yuan, Bo, Nashimoto, Masayuki
Format: Artigo
Langue:Inglês
Publié: Elsevier 2021
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7859166/
https://ncbi.nlm.nih.gov/pubmed/33553691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrep.2021.100918
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