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Plasmodium falciparum Guanylyl Cyclase-Alpha and the Activity of Its Appended P4-ATPase Domain Are Essential for cGMP Synthesis and Blood-Stage Egress

Guanylyl cyclases (GCs) synthesize cyclic GMP (cGMP) and, together with cyclic nucleotide phosphodiesterases, are responsible for regulating levels of this intracellular messenger which mediates myriad functions across eukaryotes. In malaria parasites (Plasmodium spp), as well as their apicomplexan...

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Bibliografiske detaljer
Udgivet i:mBio
Main Authors: Nofal, Stephanie D., Patel, Avnish, Blackman, Michael J., Flueck, Christian, Baker, David A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7858053/
https://ncbi.nlm.nih.gov/pubmed/33500341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02694-20
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