Paternal age affects offspring via an epigenetic mechanism involving REST/NRSF

Advanced paternal age can have deleterious effects on various traits in the next generation. Here, we establish a paternal‐aging model in mice to understand the molecular mechanisms of transgenerational epigenetics. Whole‐genome target DNA methylome analyses of sperm from aged mice reveal more hypo‐...

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Bibliographic Details
Published in:EMBO Rep
Main Authors: Yoshizaki, Kaichi, Kimura, Ryuichi, Kobayashi, Hisato, Oki, Shinya, Kikkawa, Takako, Mai, Lingling, Koike, Kohei, Mochizuki, Kentaro, Inada, Hitoshi, Matsui, Yasuhisa, Kono, Tomohiro, Osumi, Noriko
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7857438/
https://ncbi.nlm.nih.gov/pubmed/33399271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.202051524
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