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Paternal age affects offspring via an epigenetic mechanism involving REST/NRSF
Advanced paternal age can have deleterious effects on various traits in the next generation. Here, we establish a paternal‐aging model in mice to understand the molecular mechanisms of transgenerational epigenetics. Whole‐genome target DNA methylome analyses of sperm from aged mice reveal more hypo‐...
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| Veröffentlicht in: | EMBO Rep |
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| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
John Wiley and Sons Inc.
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7857438/ https://ncbi.nlm.nih.gov/pubmed/33399271 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.202051524 |
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