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A new role for matrix metalloproteinase-3 in the NGF metabolic pathway: proteolysis of mature NGF and sex-specific differences in the continuum of Alzheimer’s pathology
Matrix metalloproteinase-3 (MMP-3) has been associated with risk of Alzheimer’s disease (AD). In this study we introduce a novel role for MMP-3 in degrading nerve growth factor (NGF) in vivo and examine its mRNA and protein expression across the continuum of AD pathology. We provide evidence that MM...
Sparad:
| I publikationen: | Neurobiol Dis |
|---|---|
| Huvudupphovsmän: | , , , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2020
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7856186/ https://ncbi.nlm.nih.gov/pubmed/33130223 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2020.105150 |
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