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A new role for matrix metalloproteinase-3 in the NGF metabolic pathway: proteolysis of mature NGF and sex-specific differences in the continuum of Alzheimer’s pathology

Matrix metalloproteinase-3 (MMP-3) has been associated with risk of Alzheimer’s disease (AD). In this study we introduce a novel role for MMP-3 in degrading nerve growth factor (NGF) in vivo and examine its mRNA and protein expression across the continuum of AD pathology. We provide evidence that MM...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Neurobiol Dis
Main Authors: Pentz, Rowan, Iulita, M. Florencia, Mikutra-Cencora, Maya, Ducatenzeiler, Adriana, Bennett, David A., Cuello, A. Claudio
Format: Artigo
Jezik:Inglês
Izdano: 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7856186/
https://ncbi.nlm.nih.gov/pubmed/33130223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2020.105150
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