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Microglia depletion increase brain injury after acute ischemic stroke in aged mice
Microglia are one of the first responders to ischemic injury. Aged microglia acquire a senescent phenotype and produce more inflammatory cytokines after stroke. Depletion of microglia in young mice worsens post-ischemic damage by increasing inflammation. However, young mice do not have dysfunctional...
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| Udgivet i: | Exp Neurol |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7856174/ https://ncbi.nlm.nih.gov/pubmed/33221396 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2020.113530 |
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