The multifunctional APE1 DNA repair–redox signaling protein as a drug target in human disease

Apurinic/apyrimidinic (AP) endonuclease–reduction/oxidation factor 1 (APE1/Ref-1, also called APE1) is a multifunctional enzyme with crucial roles in DNA repair and reduction/oxidation (redox) signaling. APE1 was originally described as an endonuclease in the Base Excision Repair (BER) pathway. Furt...

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Detalhes bibliográficos
Publicado no:Drug Discov Today
Main Authors: Caston, Rachel A., Gampala, Silpa, Lee, Armstrong, Messmann, Richard A., Fishel, Melissa L., Kelley, Mark R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7855940/
https://ncbi.nlm.nih.gov/pubmed/33148489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.drudis.2020.10.015
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