A Phase Ib multicenter, dose-escalation study of the polyamine analogue PG-11047 in combination with gemcitabine, docetaxel, bevacizumab, erlotinib, cisplatin, 5-fluorouracil, or sunitinib in patients with advanced solid tumors or lymphoma.

PURPOSE: Polyamines are absolutely essential for maintaining tumor cell proliferation. PG-11047, a polyamine analogue, is a nonfunctional competitor of the natural polyamine spermine that has demonstrated anticancer activity in cells and animal models of multiple cancer types. Preclinical investigat...

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Detalhes bibliográficos
Publicado no:Cancer Chemother Pharmacol
Main Authors: Murray Stewart, Tracy, Von Hoff, Daniel, Fitzgerald, Michael, Marton, Laurence J., Becerra, Carlos H. Roberto, Boyd, Thomas E., Conkling, Paul R., Garbo, Lawrence E., Jotte, Robert M., Richards, Donald A., Smith, David A., Stephenson, Joe J., Vogelzang, Nicholas J., Wu, Hillary H., Casero, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7855804/
https://ncbi.nlm.nih.gov/pubmed/33215270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-020-04201-1
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