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A Phase I dose-escalation study of the polyamine analogue PG-11047 in patients with advanced solid tumors
PURPOSE: Polyamines are essential for the sustained proliferation and biomass required by tumor cells. Bis-alkylated polyamine analogues are nonfunctional competitors of natural polyamines. Of these, PG-11047, a second-generation unsaturated analogue of the polyamine spermine, has demonstrated antic...
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| Vydáno v: | Cancer Chemother Pharmacol |
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| Hlavní autoři: | , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2020
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7337042/ https://ncbi.nlm.nih.gov/pubmed/32447421 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-020-04082-4 |
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