The BDNF Val66Met polymorphism (rs6265) enhances dopamine neuron graft efficacy and side-effect liability in rs6265 knock-in rats

Prevalent in approximately 20% of the worldwide human population, the rs6265 (also called ‘Val66Met’) single nucleotide polymorphism (SNP) in the gene for brain-derived neurotrophic factor (BDNF) is a common genetic variant that can alter therapeutic responses in individuals with Parkinson’s disease...

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Détails bibliographiques
Publié dans:Neurobiol Dis
Auteurs principaux: Mercado, Natosha M., Stancati, Jennifer A., Sortwell, Caryl E., Mueller, Rebecca L., Boezwinkle, Samuel A., Duffy, Megan F., Fischer, D. Luke, Sandoval, Ivette M., Manfredsson, Fredric P., Collier, Timothy J., Steece-Collier, Kathy
Format: Artigo
Langue:Inglês
Publié: 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7855552/
https://ncbi.nlm.nih.gov/pubmed/33188920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2020.105175
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