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Mycobacterium tuberculosis-specific CD4 T cells expressing CD153 inversely associate with bacterial load and disease severity in human tuberculosis

Recent data from mice and non-human primate models of tuberculosis suggested that CD153, a TNF super family member, plays an important role in Mycobacterium tuberculosis (Mtb) control. However, this molecule has not been comprehensively evaluated in humans. Here, we show that the proportion of Mtb-s...

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Publicado en:Mucosal Immunol
Main Authors: Du Bruyn, Elsa, Ruzive, Sheena, Lindestam Arlehamn, Cecilia S., Sette, Alessandro, Sher, Alan, Barber, Daniel L., Wilkinson, Robert J., Riou, Catherine
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group US 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7855386/
https://ncbi.nlm.nih.gov/pubmed/32678272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41385-020-0322-6
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