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MYPT1 O-GlcNAc modification regulates sphingosine-1-phosphate mediated contraction

Many intracellular proteins are modified by N-acetylglucosamine, a posttranslational modification termed O-GlcNAc. This modification is found on serine and threonine side-chains and has the potential to regulate signaling pathways through interplay with phosphorylation. Here, we discover and charact...

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Publicado en:Nat Chem Biol
Main Authors: Pedowitz, Nichole J., Batt, Anna R., Darabedian, Narek, Pratt, Matthew R.
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7855082/
https://ncbi.nlm.nih.gov/pubmed/32929277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-020-0640-8
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