Liver Injury Increases the Incidence of HCC following AAV Gene Therapy in Mice

Adeno-associated virus (AAV) integrates into host genomes at low frequency, but when integration occurs in oncogenic hotspots it can cause hepatocellular carcinoma (HCC). Given the possibility of recombinant AAV (rAAV) integration leading to HCC, common causes of liver inflammation like non-alcoholi...

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發表在:Mol Ther
Main Authors: Dalwadi, Dhwanil A., Torrens, Laura, Abril-Fornaguera, Jordi, Pinyol, Roser, Willoughby, Catherine, Posey, Jeffrey, Llovet, Josep M., Lanciault, Christian, Russell, David W., Grompe, Markus, Naugler, Willscott E.
格式: Artigo
語言:Inglês
出版: American Society of Gene & Cell Therapy 2021
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Original Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7854305/
https://ncbi.nlm.nih.gov/pubmed/33554867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2020.10.018
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