Phylogenomics of 8,839 Clostridioides difficile genomes reveals recombination-driven evolution and diversification of toxin A and B

Clostridioides difficile is the major worldwide cause of antibiotic-associated gastrointestinal infection. A pathogenicity locus (PaLoc) encoding one or two homologous toxins, toxin A (TcdA) and toxin B (TcdB), is essential for C. difficile pathogenicity. However, toxin sequence variation poses majo...

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Gepubliceerd in:PLoS Pathog
Hoofdauteurs: Mansfield, Michael J., Tremblay, Benjamin J-M, Zeng, Ji, Wei, Xin, Hodgins, Harold, Worley, Jay, Bry, Lynn, Dong, Min, Doxey, Andrew C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2020
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7853461/
https://ncbi.nlm.nih.gov/pubmed/33370413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1009181
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