Pyrroline-5-carboxylate synthase senses cellular stress and modulates metabolism by regulating mitochondrial respiration

Pyrroline-5-carboxylate synthase (P5CS) catalyzes the synthesis of pyrroline-5-carboxylate (P5C), a key precursor for the synthesis of proline and ornithine. P5CS malfunction leads to multiple human diseases; however, the molecular mechanism underlying these diseases is unknown. We found that P5CS l...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Yang, Zhaoying, Zhao, Xiaocui, Shang, Weina, Liu, Yang, Ji, Jun-Feng, Liu, Jun-Ping, Tong, Chao
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7853148/
https://ncbi.nlm.nih.gov/pubmed/32770108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-020-0601-5
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