A novel selective autophagy receptor, CCDC50, delivers K63 polyubiquitination-activated RIG-I/MDA5 for degradation during viral infection

Autophagy is a conserved process that delivers cytosolic substances to the lysosome for degradation, but its direct role in the regulation of antiviral innate immunity remains poorly understood. Here, through high-throughput screening, we discovered that CCDC50 functions as a previously unknown auto...

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Detalhes bibliográficos
Publicado no:Cell Res
Main Authors: Hou, Panpan, Yang, Kongxiang, Jia, Penghui, Liu, Lan, Lin, Yuxin, Li, Zibo, Li, Jun, Chen, Shuliang, Guo, Shuting, Pan, Ji’An, Wu, Junyu, Peng, Hong, Zeng, Weijie, Li, Chunmei, Liu, Yingfang, Guo, Deyin
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Singapore 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7852694/
https://ncbi.nlm.nih.gov/pubmed/32612200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41422-020-0362-1
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