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Activation of proprotein convertase in the mouse habenula causes depressive-like behaviors through remodeling of extracellular matrix

The lateral habenula (LHb) attracts a growing interest as a regulator of monoaminergic activity which were frequently reported to be defective in depression. Here we found that chronic social defeat stress (CSDS) increased production of pro-inflammatory cytokines in LHb associated with mobilization...

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Publicat a:Neuropsychopharmacology
Autors principals: Ito, Hikaru, Nozaki, Kanako, Sakimura, Kenji, Abe, Manabu, Yamawaki, Shigeto, Aizawa, Hidenori
Format: Artigo
Idioma:Inglês
Publicat: Springer International Publishing 2020
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7852607/
https://ncbi.nlm.nih.gov/pubmed/32942293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41386-020-00843-0
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