Sequence signatures of two IGHV3-53/3-66 public clonotypes to SARS-CoV-2 receptor binding domain

Since the COVID-19 pandemic onset, the antibody response to SARS-CoV-2 has been extensively characterized. Antibodies to the receptor binding domain (RBD) on the spike protein are frequently encoded by IGHV3-53/3-66 with a short CDR H3. Germline-encoded sequence motifs in CDRs H1 and H2 play a major...

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Detalhes bibliográficos
Publicado no:bioRxiv
Main Authors: Tan, Timothy J.C., Yuan, Meng, Kuzelka, Kaylee, Padron, Gilberto C., Beal, Jacob R., Chen, Xin, Wang, Yiquan, Rivera-Cardona, Joel, Zhu, Xueyong, Stadtmueller, Beth M., Brooke, Christopher B., Wilson, Ian A., Wu, Nicholas C.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7852275/
https://ncbi.nlm.nih.gov/pubmed/33532781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.01.26.428356
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