Potent and protective IGHV3-53/3-66 public antibodies and their shared escape mutant on the spike of SARS-CoV-2

Neutralizing antibodies (nAbs) to SARS-CoV-2 hold powerful potentials for clinical interventions against COVID-19 disease. However, their common genetic and biologic features remain elusive. Here we interrogate a total of 165 antibodies from eight COVID-19 patients, and find that potent nAbs from di...

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Publicado en:Nat Commun
Main Authors: Zhang, Qi, Ju, Bin, Ge, Jiwan, Chan, Jasper Fuk-Woo, Cheng, Lin, Wang, Ruoke, Huang, Weijin, Fang, Mengqi, Chen, Peng, Zhou, Bing, Song, Shuo, Shan, Sisi, Yan, Baohua, Zhang, Senyan, Ge, Xiangyang, Yu, Jiazhen, Zhao, Juanjuan, Wang, Haiyan, Liu, Li, Lv, Qining, Fu, Lili, Shi, Xuanling, Yuen, Kwok Yung, Liu, Lei, Wang, Youchun, Chen, Zhiwei, Zhang, Linqi, Wang, Xinquan, Zhang, Zheng
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8270942/
https://ncbi.nlm.nih.gov/pubmed/34244522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24514-w
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