TREM2 is thyroid hormone regulated making the TREM2 pathway druggable with ligands for thyroid hormone receptor

Triggering receptor expressed on myeloid cells-2 (TREM2) is a cell surface receptor on macrophages and microglia that senses and responds to disease associated signals to regulate the phenotype of these innate immune cells. The TREM2 signaling pathway has been implicated in a variety of diseases ran...

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Detalhes bibliográficos
Publicado no:bioRxiv
Main Authors: Ferrara, Skylar J., Chaudhary, Priya, DeBell, Margaret J., Marracci, Gail, Miller, Hannah, Calkins, Evan, Pocius, Edvinas, Napier, Brooke A., Emery, Ben, Bourdette, Dennis, Scanlan, Thomas S.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7852265/
https://ncbi.nlm.nih.gov/pubmed/33532772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.01.25.428149
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