Fluoxetine regulates eEF2 activity (phosphorylation) via HDAC1 inhibitory mechanism in an LPS-induced mouse model of depression

BACKGROUND: Selective serotonin reuptaker inhibitors, including fluoxetine, are widely studied and prescribed antidepressants, while their exact molecular and cellular mechanism are yet to be defined. We investigated the involvement of HDAC1 and eEF2 in the antidepressant mechanisms of fluoxetine us...

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Publicado en:J Neuroinflammation
Autores principales: Li, Weifen, Ali, Tahir, Zheng, Chengyou, Liu, Zizhen, He, Kaiwu, Shah, Fawad Ali, Ren, Qingguo, Rahman, Shafiq Ur, Li, Ningning, Yu, Zhi-Jian, Li, Shupeng
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7852137/
https://ncbi.nlm.nih.gov/pubmed/33526073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-021-02091-5
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