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PP1 promotes cyclin B destruction and the metaphase–anaphase transition by dephosphorylating CDC20
Ubiquitin-dependent proteolysis of cyclin B and securin initiates sister chromatid segregation and anaphase. The anaphase-promoting complex/cyclosome and its coactivator CDC20 (APC/C(CDC20)) form the main ubiquitin E3 ligase for these two proteins. APC/C(CDC20) is regulated by CDK1-cyclin B and coun...
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| Publicado no: | Mol Biol Cell |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Cell Biology
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7851957/ https://ncbi.nlm.nih.gov/pubmed/32755477 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E20-04-0252 |
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