Mesenchymal stem cell-derived interleukin-28 drives the selection of apoptosis resistant bone metastatic prostate cancer

Bone metastatic prostate cancer (PCa) promotes mesenchymal stem cell (MSC) recruitment and their differentiation into osteoblasts. However, the effects of bone-marrow derived MSCs on PCa cells are less explored. Here, we report MSC-derived interleukin-28 (IL-28) triggers prostate cancer cell apoptos...

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Publié dans:Nat Commun
Auteurs principaux: McGuire, Jeremy J., Frieling, Jeremy S., Lo, Chen Hao, Li, Tao, Muhammad, Ayaz, Lawrence, Harshani R., Lawrence, Nicholas J., Cook, Leah M., Lynch, Conor C.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2021
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7851397/
https://ncbi.nlm.nih.gov/pubmed/33526787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-20962-6
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