Acetyl-bufalin shows potent efficacy against non-small-cell lung cancer by targeting the CDK9/STAT3 signalling pathway

BACKGROUND: Cyclin-dependent kinase 9 (CDK9) is a promising prognostic marker and therapeutic target in cancers. Bufalin is an effective anti-tumour agent; however, the clinical application of bufalin is limited due to its high toxicity. Acetyl-bufalin, the bufalin prodrug, was designed and synthesi...

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Publicado no:Br J Cancer
Main Authors: Yang, Lehe, Zhou, Feng, Zhuang, Yan, Liu, Yanan, Xu, Lingyuan, Zhao, Haiyang, Xiang, Youqun, Dai, Xuanxuan, Liu, Zhiguo, Huang, Xiaoying, Wang, Liangxing, Zhao, Chengguang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7851395/
https://ncbi.nlm.nih.gov/pubmed/33122847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-020-01135-6
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