SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species

The genome of SARS-CoV-2 encodes two viral proteases (NSP3/papain-like protease and NSP5/3C-like protease) that are responsible for cleaving viral polyproteins during replication. Here, we discovered new functions of the NSP3 and NSP5 proteases of SARS-CoV-2, demonstrating that they could directly c...

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Bibliographische Detailangaben
Veröffentlicht in:Emerg Microbes Infect
Hauptverfasser: Moustaqil, Mehdi, Ollivier, Emma, Chiu, Hsin-Ping, Van Tol, Sarah, Rudolffi-Soto, Paulina, Stevens, Christian, Bhumkar, Akshay, Hunter, Dominic J. B., Freiberg, Alexander N., Jacques, David, Lee, Benhur, Sierecki, Emma, Gambin, Yann
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2021
Schlagworte:
Coronaviruses
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7850364/
https://ncbi.nlm.nih.gov/pubmed/33372854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/22221751.2020.1870414
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