5′ValCAC tRNA fragment generated as part of a protective angiogenin response provides prognostic value in amyotrophic lateral sclerosis

Loss-of-function mutations in the ribonuclease angiogenin are associated with amyotrophic lateral sclerosis. Angiogenin has been shown to cleave transfer RNAs during stress to produce ‘transfer-derived stress-induced RNAs’. Stress-induced tRNA cleavage is preserved from single-celled organisms to hu...

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Detalhes bibliográficos
Publicado no:Brain Commun
Main Authors: Hogg, Marion C, Rayner, Megan, Susdalzew, Sergej, Monsefi, Naser, Crivello, Martin, Woods, Ina, Resler, Alexa, Blackbourn, Lisle, Fabbrizio, Paola, Trolese, Maria Chiara, Nardo, Giovanni, Bendotti, Caterina, van den Berg, Leonard H, van Es, Michael A, Prehn, Jochen H M
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7850272/
https://ncbi.nlm.nih.gov/pubmed/33543130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/braincomms/fcaa138
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