Niche-specific MHC II and PD-L1 regulate CD4(+)CD8αα(+) intraepithelial lymphocyte differentiation

Conventional CD4(+) T cells are differentiated into CD4(+)CD8αα(+) intraepithelial lymphocytes (IELs) in the intestine; however, the roles of intestinal epithelial cells (IECs) are poorly understood. Here, we showed that IECs expressed MHC class II (MHC II) and programmed death–ligand 1 (PD-L1) indu...

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Vydáno v:J Exp Med
Hlavní autoři: Moon, Sookjin, Park, Yunji, Hyeon, Sumin, Kim, Young-Min, Kim, Ji-Hae, Kim, Hyekang, Park, Subin, Lee, Kun-Joo, Koo, Bon-Kyoung, Ha, Sang-Jun, Lee, Seung-Woo
Médium: Artigo
Jazyk:Inglês
Vydáno: Rockefeller University Press 2021
Témata:
Brief Definitive Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7849820/
https://ncbi.nlm.nih.gov/pubmed/33533917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20201665
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