Control of CD8αα intestinal intraepithelial lymphocyte development by TGF-β

The molecular mechanisms directing the development of TCRαβ(+)CD8αα(+) intestinal intraepithelial lymphocytes (IEL) are not thoroughly understood. Here we show that transforming growth factor-β (TGF-β) controls the development of TCRαβ(+)CD8αα(+) IEL. Mice with either a TGF-β1 null mutation or a T c...

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Autori principali: Konkel, Joanne E., Maruyama, Takashi, Carpenter, Andrea C., Xiong, Yumei, Zamarron, Brian F., Hall, Bradford E., Kulkarni, Ashok, Zhang, Pin, Bosselut, Remy, Chen, WanJun
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3062738/
https://ncbi.nlm.nih.gov/pubmed/21297643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1997
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