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LRRK2 binds to the Rab32 subfamily in a GTP-dependent manner via its armadillo domain
LRRK2 is a multi-domain Ser/Thr kinase that is associated with inherited and sporadic cases of Parkinson’s disease. Many mutations linked to disease are associated within a central ROC-COR regulatory region and the subsequent kinase domain, leading to enhanced catalytic activity. The N-terminus of h...
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| Udgivet i: | Small GTPases |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Taylor & Francis
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7849779/ https://ncbi.nlm.nih.gov/pubmed/31552791 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21541248.2019.1666623 |
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