Ataxia-telangiectasia mutated interacts with Parkin and induces mitophagy independent of kinase activity. Evidence from mantle cell lymphoma

Ataxia telangiectasia mutated (ATM), a critical DNA damage sensor with protein kinase activity, is frequently altered in human cancers including mantle cell lymphoma. Loss of ATM protein is linked to accumulation of nonfunctional mitochondria and defective mitophagy in both murine thymocytes and in...

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Xehetasun bibliografikoak
Argitaratua izan da:Haematologica
Egile Nagusiak: Sarkar, Aloke, Stellrecht, Christine M., Vangapandu, Hima V., Ayres, Mary, Kaipparettu, Benny A., Park, Jun Hyoung, Balakrishnan, Kumudha, Burks, Jared K., Pandita, Tej K., Hittelman, Walter N., Neelapu, Sattva S., Gandhi, Varsha
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Fondazione Ferrata Storti 2020
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7849759/
https://ncbi.nlm.nih.gov/pubmed/32029507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2019.234385
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