Ataxia-telangiectasia mutated interacts with Parkin and induces mitophagy independent of kinase activity. Evidence from mantle cell lymphoma

Ataxia telangiectasia mutated (ATM), a critical DNA damage sensor with protein kinase activity, is frequently altered in human cancers including mantle cell lymphoma. Loss of ATM protein is linked to accumulation of nonfunctional mitochondria and defective mitophagy in both murine thymocytes and in...

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Detalhes bibliográficos
Publicado no:Haematologica
Main Authors: Sarkar, Aloke, Stellrecht, Christine M., Vangapandu, Hima V., Ayres, Mary, Kaipparettu, Benny A., Park, Jun Hyoung, Balakrishnan, Kumudha, Burks, Jared K., Pandita, Tej K., Hittelman, Walter N., Neelapu, Sattva S., Gandhi, Varsha
Formato: Artigo
Idioma:Inglês
Publicado em: Fondazione Ferrata Storti 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7849759/
https://ncbi.nlm.nih.gov/pubmed/32029507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2019.234385
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