Proline hydroxylation primes protein kinases for autophosphorylation and activation

Activation of dual specificity tyrosine-phosphorylation-regulated kinases 1A and 1B (DYRK1A and DYRK1B) requires prolyl-hydroxylation by PHD1 prolyl hydroxylase. Prolyl-hydroxylation of DYRK1 initiates a cascade of events leading to the release of molecular constraints on VHL ubiquitin ligase tumor...

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Bibliografiska uppgifter
I publikationen:Mol Cell
Huvudupphovsmän: Lee, Sang Bae, Ko, Aram, Oh, Young Taek, Shi, Peiguo, D’Angelo, Fulvio, Frangaj, Brulinda, Koller, Antonius, Chen, Emily I., Cardozo, Timothy, lavarone, Antonio, Lasorella, Anna
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7849370/
https://ncbi.nlm.nih.gov/pubmed/32640193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.06.021
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