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AAV-CRB2 protects against vision loss in an inducible CRB1 retinitis pigmentosa mouse model
Loss of Crumbs homolog 1 (CRB1) or CRB2 proteins in Müller cells or photoreceptors in the mouse retina results in a CRB dose-dependent retinal phenotype. In this study, we present a novel Müller cell-specific Crb1(KO)Crb2(LowMGC) retinitis pigmentosa mouse model (complete loss of CRB1 and reduced le...
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| Publicado no: | Mol Ther Methods Clin Dev |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Gene & Cell Therapy
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7848734/ https://ncbi.nlm.nih.gov/pubmed/33575434 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2020.12.012 |
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