AAV-CRB2 protects against vision loss in an inducible CRB1 retinitis pigmentosa mouse model

Loss of Crumbs homolog 1 (CRB1) or CRB2 proteins in Müller cells or photoreceptors in the mouse retina results in a CRB dose-dependent retinal phenotype. In this study, we present a novel Müller cell-specific Crb1(KO)Crb2(LowMGC) retinitis pigmentosa mouse model (complete loss of CRB1 and reduced le...

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Bibliografische gegevens
Gepubliceerd in:Mol Ther Methods Clin Dev
Hoofdauteurs: Buck, Thilo M., Vos, Rogier M., Alves, C. Henrique, Wijnholds, Jan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Gene & Cell Therapy 2020
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Original Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7848734/
https://ncbi.nlm.nih.gov/pubmed/33575434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2020.12.012
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