Mechanism of how carbamylation reduces albumin binding to FcRn contributing to increased vascular clearance

Chronic kidney disease results in high serum urea concentrations leading to excessive protein carbamylation, primarily albumin. This is associated with increased cardiovascular disease and mortality. Multiple methods were used to address whether carbamylation alters albumin metabolism. Intravital tw...

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Veröffentlicht in:Am J Physiol Renal Physiol
Hauptverfasser: Yadav, Shiv Pratap S., Sandoval, Ruben M., Zhao, Jingfu, Huang, Yifan, Wang, Exing, Kumar, Sudhanshu, Campos-Bilderback, Silvia B., Rhodes, George, Mechref, Yehia, Molitoris, Bruce A., Wagner, Mark C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2021
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7847050/
https://ncbi.nlm.nih.gov/pubmed/33283642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00428.2020
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