Mechanism of how carbamylation reduces albumin binding to FcRn contributing to increased vascular clearance

Chronic kidney disease results in high serum urea concentrations leading to excessive protein carbamylation, primarily albumin. This is associated with increased cardiovascular disease and mortality. Multiple methods were used to address whether carbamylation alters albumin metabolism. Intravital tw...

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Detalhes bibliográficos
Publicado no:Am J Physiol Renal Physiol
Main Authors: Yadav, Shiv Pratap S., Sandoval, Ruben M., Zhao, Jingfu, Huang, Yifan, Wang, Exing, Kumar, Sudhanshu, Campos-Bilderback, Silvia B., Rhodes, George, Mechref, Yehia, Molitoris, Bruce A., Wagner, Mark C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7847050/
https://ncbi.nlm.nih.gov/pubmed/33283642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00428.2020
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